STAT Protein Inhibitor Database

We proudly present the first interactive database devoted to compounds inhibiting STAT signalling pathways.

What you can do:

  • Investigate compounds inhibiting directly/indirectly STAT proteins
  • Analyse experiments that were conducted for available inhibitors
  • See available 3D visualizations of docking to STAT-SH2 domains
  • Get information on clinical trials
  • Download data
  • See statistical analysis for investigated conditions

You can find STAT Inhbitor Biology and Drugability (SINBAD) here: SINBAD

2020 articles

Check our articles published in 2020:

  1. Arkadiusz Kajdasz, Ewelina Warzych, Natalia Derebecka, Zofia E. Madeja, Dorota Lechniak, Joanna Wesoly and Piotr Pawlak
    Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovine Parthenogenetic Embryos Revealed by Fluorescent Staining and RNA-seq
    Int. J. Mol. Sci. 2020, 21(18), 6488;
  2. David Ballard, Jakub Winkler-Galicki, Joanna Wesoły
    Massive parallel sequencing in forensics: advantages, issues, technicalities and prospects

    Int J Legal Med. 2020; 134(4): 1291–1303. doi: 10.1007/s00414-020-02294-0. PubMed
  3.  Ryszard KrzyminiewskiBernadeta DoboszBart KristGrzegorz SchroederJoanna KurczewskaHans A R Bluyssen
    ESR Method in Monitoring of Nanoparticle Endocytosis in Cancer Cells

    Int J Mol Sci. 2020 Jun 19;21(12):E4388. doi: 10.3390/ijms21124388. PubMed
  4. Golsorkhdan SA*, Boroujeni ME*, Aliaghaei A, Abdollahifar MA, Ramezanpour A, Nejatbakhsh R, Anarkooli IJ, Barfi E, Fridoni MJ
    Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus
    FBehav Brain Res. 2020 Feb 3;379:112300. doi: 10.1016/j.bbr.2019.112300. PubMed
    * Authors contributed equally to this work
  5. Akhlaghpasand MH, Tizro M, Raoofi A, Meymand AZ, Farhadieh M, Khodagholi F, Khatmi A, Soltani R, Hoseini Y, Jahanian A, Boroujeni ME*, Aliaghaei A*
    Grafted Human Chorionic Stem Cells Restore Motor Function and Preclude Cerebellar Neurodegeneration in Rat Model of Cerebellar Ataxia
    Metabolic Brain Disease. DOI: 10.1007/s11011-020-00543-0
    * Corresponding authors

The list of all our publications you can find here.

New paper published: Signal Integration of IFN-I and IFN-II with TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription

On the 17th of May the research article of Anna Piaszyk-Borychowska, Lajos Széles, Attila Csermely, Hsin-Chien Chiang, Joanna Wesoły, Chien-Kuo Lee, Laszlo Nagy and Hans A. R. Bluyssen was accepted and published in Frontiers in Immunology, in the special research topic STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets on June 4th. The full-length article can be viewed via the link.

New review paper published: Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated with Disease

On the 9th of May the review article of Aleksandra Antonczyk1, Bart Krist1, Malgorzata Sajek, Agata Michalska, Anna Piaszyk-Borychowska, Martyna Plens-Galaska, Joanna Wesoly and Hans A. R. Bluyssen was accepted and published in Frontiers in Immunology, in the special research topic STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets on May 24th. The full-length article can be viewed via the link.

PhD procedure opening

On 8th March 2019 our PhD candidate, Agata Michalska opened PhD procedure. She gave a presentation entitled “Characterization of a novel intracellular positive feedback loop that controls long-term responsiveness to type I and II IFN”.

You can see on the selfie how happy is Agata after the seminar  🙂 Good job!

Course in Warsaw, 18-22.02.2019

Our PhD students, Aleksandra Antończyk, Martyna Plens-Gałąska and Agata Michalska, participated in the course for researchers, who want to plan, design and/or conduct animal experiments. Lectures took place at the University of Warsaw Biological and Chemical Research Centre and were organized by Polish Laboratory Animal Science Association (PolLASA).

Postdoc position

The Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznan, headed by Prof. dr hab. Hans A.R. Bluyssen, invites applications for a postdoctoral position.

The position is currently available and funded by the National Science Centre within OPUS grant UMO-2016/23/B/NZ2/00623, entitled: “Characterization of a novel intracellular amplifier circuit that controls long-term responsiveness to type I and type II IFNs.”

The project combines state of the art technologies with a highly ambitious and competitive research environment.

More information

Cattle-based agriculture in the Early and Middle Neolithic in the Polish lowlands – genetic and zooarchaeological characterization.

We are happy to inform you that the LHTT in cooperation with prof. dr hab. Arkadiusz Marciniak (Faculty of History, AMU) will take part in the grant from NCN entitled “Cattle-based agriculture in the Early and Middle Neolithic in the Polish lowlands – genetic and zooarchaeological characterization”.